Immunologie intégrative des tumeurs et immunothérapie des cancers (INTIM)

Laboratory presentation

The laboratory Tumor Integrative Immunology is studying tumor antigens, T-cell reactivity, the impact of the tumor microenvironment on tumor resistance (role on plasticity in particular) and more generally genetics and biology of breast cancer, lung, kidneys and cancers related to melanomas. This work are undertaken thanks to partnerships with industrial companies, which has allowed 2 patents filing as well as the creation of 2 startups and the development of new innovative immunotherapy approaches.

The 20 latest publications

Title Authors Publication date Source
Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti-PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma Marie Breckler, Nathalie Droin 04/03/23 Cancer Discovery
Nonskeletal and skeletal effects of high doses versus low doses of vitamin D<inf>3</inf> in renal transplant recipients: Results of the VITALE (VITamin D supplementation in renAL transplant recipients) study, a randomized clinical trial Antoine Durrbach 03/01/23 American Journal of Transplantation
Progressive Multifocal Leukoencephalopathy Treated by Immune Checkpoint Inhibitors Jacques Gasnault 02/01/23 Annals of Neurology
Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to Therapy Salem Chouaib 02/01/23 Cancers
State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer Salem Chouaib 01/01/23 Frontiers in Oncology
FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites Jean Paul Thiery 01/01/23 Theranostics
Jejunum-derived NF-κB reporter organoids as 3D models for the study of TNF-alpha-induced inflammation Flora Doffe 12/01/22 Scientific Reports
Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers Lydie Cassard, Lisa Boselli, Jonathan Grivel, Ludovic Lacroix, N. Chaput 12/01/22 Journal of Experimental and Clinical Cancer Research
Editorial: The intricate innate immune-cancer cell relationship in the context of tumor angiogenesis, immunity and microbiota: The angiogenic switch in the tumor microenvironment as a key target for immunotherapies Salem Chouaib 10/06/22 Frontiers in Immunology
Designing Organoid Models to Monitor Cancer Progression, Plasticity and Resistance: The Right Set Up for the Right Question Flora Doffe, Stéphane Terry, Salem Chouaib, Pierre Savagner 08/01/22 Cancers
The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy: Mirage or Reality? Salem Chouaib 06/20/22 Frontiers in Immunology
BCG therapy downregulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer Julien Adam 06/15/22 Journal of Clinical Investigation
Genomic Analysis of Waterpipe Smoke-Induced Lung Tumor Autophagy and Plasticity Salem Chouaib 06/01/22 International Journal of Molecular Sciences
Vaccine Therapy in Non-Small Cell Lung Cancer Stéphanie Corgnac 05/01/22 Vaccines
Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition Jean Paul Thiery, Salem Chouaib, Stéphane Terry 04/27/22 Frontiers in Immunology
Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models Jean Paul Thiery 04/22/22 Frontiers in Oncology
Cancer stem-like cells evade CD8<sup>+</sup>CD103<sup>+</sup> tumor-resident memory T (T<inf>RM</inf>) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model Stéphanie Corgnac, Isabelle Damei, Gwendoline Gros, Aziza Caidi, Stéphane Terry, Salem Chouaib, Fathia Mami-Chouaib 04/13/22 Journal for ImmunoTherapy of Cancer
Outcome of Progressive Multifocal Leukoencephalopathy Treated by Interleukin-7 Jacques Gasnault 04/01/22 Annals of Neurology
Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach Salem Chouaib 03/01/22 Pharmacology and Therapeutics
The Effect of Hypoxia and Hypoxia-Associated Pathways in the Regulation of Antitumor Response: Friends or Foes? Jérome Thiery, Stéphane Terry, Salem Chouaib 02/08/22 Frontiers in Immunology

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)