Immunologie anti-tumorale et immunothérapie des cancers (ITIC)

Laboratory presentation

The laboratory of cancer immunology and immunotherapy against cancer has 2 major research themes. The first is the immunology of tumors and immunotherapy against cancer and the second is the role of mRNA translation in the antigen presentation. These topics include studies on the intestinal microbiota and tumors inflammation, immunotherapy customized by monoclonal antibodies or on the cross-presentation to MHC class I on antigenic peptides. This research focuses on a better understanding of immunology in cancer patients and to improve personalized treatments to better fight this disease. This work in partnership with numerous industrial partners has already enabled the implementation of 6 patents.

The 20 latest publications

Title Authors Publication date Source
Introduction to the Special Issue: Nutrition, microbiota and immunity Laurence Zitvogel 05/01/23 Seminars in Immunology
MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation Florent Ginhoux 05/01/23 Nature Immunology
Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti-PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma Marie Breckler, Nathalie Droin 04/03/23 Cancer Discovery
Seasonality of main childhood embryonal tumours and rhabdomyosarcoma, France, 2000–2015 Veronique Minard-Colin 04/01/23 Cancer Medicine
Changing incentives to ACCELERATE drug development for paediatric cancer Gilles Vassal 04/01/23 Cancer Medicine
Analysis of Aβ-induced neurotoxicity and microglial responses in simple two- and three-dimensional human iPSC-derived cortical culture systems Florent Ginhoux 04/01/23 Tissue and Cell
Rationale for LDH-targeted cancer immunotherapy Tina B.S. Miholjcic, Heloise Halse, Mélodie Bonvalet, Amélie Bigorgne, Mathieu Rouanne, Aurélien Marabelle 03/01/23 European Journal of Cancer
High caspase 3 and vulnerability to dual BCL2 family inhibition define ETO2::GLIS2 pediatric leukemia Laure Touchard, Yann Lecluse 03/01/23 Leukemia
Biological Role and Clinical Implications of MYOD1<sup>L122R</sup> Mutation in Rhabdomyosarcoma Veronique Minard-Colin 03/01/23 Cancers
Paradoxical cancer cell stimulation by IFNγ drives tumor hyperprogression upon checkpoint blockade immunotherapy Stéphane Champiat, Aurélien Marabelle 02/13/23 Cancer Cell
Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to Therapy Salem Chouaib 02/01/23 Cancers
Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600-Mutant Low-Grade Glioma Birgit Geoerger 01/20/23 Journal of Clinical Oncology
Characterization of Developmental Trajectories of Dendritic Cell Hematopoiesis Through Single-Cell RNA Sequencing Methods Florent Ginhoux 01/01/23 Methods in molecular biology (Clifton, N.J.)
Safety and efficacy of the anti-PD1 immunotherapy with nivolumab in trichoblastic carcinomas Aurélien Marabelle 01/01/23 Cancer Immunology, Immunotherapy
Intratumoral Immunotherapy: Is It Ready for Prime Time? Lambros Tselikas, Stéphane Champiat, François Xavier Danlos, Sandrine Susini, Aurélien Marabelle 01/01/23 Current Oncology Reports
Bodywide ecological interventions on cancer Laurence Zitvogel 01/01/23 Nature Medicine
RBD- specific Th1 responses are associated with vaccine-induced protection against SARS-CoV-2 infection in patients with hematological malignancies Camille Bigenwald, Yacine Haddad, Cassandra Thelemaque, Agathe Carrier, Roxanne Birebent, Pierre Ly, Caroline Flament, Imran Lahmar, Aurélien Marabelle, Lisa Derosa, Laurence Zitvogel 01/01/23 OncoImmunology
Tumor-infiltrating lymphocytes for melanoma immunotherapy Laurence Zitvogel 01/01/23 OncoImmunology
Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Florent Ginhoux 12/29/22 Viruses
Epidemiological Study to Assess the Prevalence of Lung Cancer in patients with smoking-associated atherosclerotic cardiovascular diseases: PREVALUNG study protocol M. Fidelle, Laurence Zitvogel 12/26/22 BMJ Open

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)