Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT)

Laboratory presentation

Inserm UMR-S 999 is a major actor in national and international translational research on pulmonary hypertension, leading to major physiopathological, medical and surgical advances. It is subdivided into two research, physiopathological and clinical teams composed of researchers, clinicians and surgeons who have been working in synergy since 2010. Thanks to a national register of patients (National Reference Center for Severe Pulmonary Hypertension), a biobank of cells and tissues, and an internationally recognized expertise, the two teams are studying the mechanisms of pulmonary vascular remodeling and associated heart disease in humans, rodents and large animals.

The 20 latest publications

Title Authors Publication date Source
AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery Ly Tu, Raphaël Thuillet, Mina Ottaviani, Christophe Guignabert 05/05/23 European Journal of Pharmacology
Evolution of Ultrasound-Assessed Lung Aeration and Gas Exchange in Respiratory Distress Syndrome and Transient Tachypnea of the Neonate D. De Luca 05/01/23 Journal of Pediatrics
Multiparametric evaluation of right ventricular function in pulmonary arterial hypertension associated with congenital heart disease Estibaliz Valdeolmillos, Marc Humbert, Olivier Sitbon, Xavier Jaïs, Laurent Savale, David Montani, Elie Fadel, Sebastien Hascoët 05/01/23 Revista Espanola de Cardiologia
Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension Marius M. Hoeper, David B. Badesch, H. Ardeschir Ghofrani, J. Simon R. Gibbs, Mardi Gomberg-Maitland, Vallerie V. McLaughlin, Ioana R. Preston, Rogerio Souza, Aaron B. Waxman, Ekkehard Grünig, Grzegorz Kopeć, Gisela Meyer, Karen M. Olsson, Stephan Rosen… 04/20/23 New England Journal of Medicine
Health-Related Quality of Life and Its Association With Outcomes in Adults With Congenital Heart Disease and Heart Failure: Insight From FRESH-ACHD Registry Sarah Cohen, Jelena Radojevic, Sebastien Hascoët 04/18/23 Journal of the American Heart Association
Monitoring of Hemodynamics With Right Heart Catheterization in Children With Pulmonary Arterial Hypertension Julien Grynblat, Frédéric Perros, Marc Humbert, I. David Montani 04/04/23 Journal of the American Heart Association
European Society of Cardiology quality indicators for the care and outcomes of adults with pulmonary arterial hypertension. Developed in collaboration with the Heart Failure Association of the European Society of Cardiology Marc Humbert, Olivier Sitbon 04/01/23 European Journal of Heart Failure
Follow-up strategies for lung transplant recipients in France Jérôme Le Pavec 04/01/23 Revue des Maladies Respiratoires
Continuous Venovenous Hemofiltration Performed by Neonatologists With Cardio-Renal Pediatric Dialysis Emergency Machine to Treat Fluid Overload During Multiple Organ Dysfunction Syndrome: A Case Series D. De Luca 04/01/23 Pediatric Critical Care Medicine
mTOR Inhibition Impairs the Activation and Function of Belatacept-Resistant CD4<sup>+</sup>CD57<sup>+</sup> T Cells In Vivo and In Vitro Jérôme Le Pavec, Olaf Mercier, Elie Fadel 04/01/23 Pharmaceutics
The flare of care for rare: per aspera ad astra for rare lung diseases! Marc Humbert 03/31/23 European Respiratory Review
Highlights from the International Chronic Thromboembolic Pulmonary Hypertension Congress 2021 Elie Fadel 03/31/23 European Respiratory Review
Ordinal outcomes add value to clinical trials – Authors' reply Marc Humbert 03/25/23 The Lancet
Infective endocarditis after transcatheter pulmonary valve implantation in patients with congenital heart disease: Distinctive features Estibaliz Valdeolmillos, Sebastien Hascoët 03/01/23 Archives of Cardiovascular Diseases
Discussion about the presentation: “Pathophysiology and treatment of pulmonary hypertension” Marc Humbert 03/01/23 Bulletin de l'Academie Nationale de Medecine
Multicenter experience of transcatheter correction of superior sinus venosus defect using the covered Optimus XXL stent Clement Batteux, Sebastien Hascoët 03/01/23 Revista Espanola de Cardiologia
Update of indications and contra indications for lung transplantation in 2022 Jérôme Le Pavec 03/01/23 Revue des Maladies Respiratoires
Lung transplantation contra-indications Jérôme Le Pavec 03/01/23 Revue des Maladies Respiratoires
Indications plus rares de transplantation pulmonaire et circonstances particulières: réaction du greffon contre l'hôte pulmonaire post allogreffe de moelle osseuse Jérôme Le Pavec 03/01/23 Revue des Maladies Respiratoires
Lung transplantation for severe pulmonary hypertension Jérôme Le Pavec, Laurent Savale, David Montani, Olivier Sitbon, Marc Humbert 03/01/23 Revue des Maladies Respiratoires

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)