Chimie et modélisation pour la biologie du cancer (CMBC)

Laboratory presentation

The central activity of the CMIB unit is to develop small molecules to investigate and control the biological activities of the main targets involved in cancer. These are essentially non-B (quadruplex) nucleic acid structures and kinases. IR-photoexcitable probes designed for both subcellular monitoring and targeted photo-aging are also important research axes. The drug and probe design activity is supported by the molecular modeling approach and Multimodal imaging (TEM, NanoSIMS, MRI). These approaches include the development of image processing and analysis methods as well as the design of software tools and protocols for biology imaging. The CMIB unit hosts the Institut Curie-CNRS library, 9000 chemical compounds, preclinical MRI imaging and chemical imaging platforms.

The 20 latest publications

Title Authors Publication date Source
PSL Chemical Biology Symposia Third Edition: A Branch of Science in its Explosive Phase Boris Vauzeilles, Géraldine Masson 04/17/23 ChemBioChem
TRANSLACOL project: Nodal human papillomavirus tumoral DNA detection by ddPCR for survival prediction in early cervical cancer patients without pelvic lymph node invasion Pascal Rigolet 04/01/23 Journal of Clinical Virology
Two-photon absorption in imidazo[1,2-a]pyridine derivatives: Study of nonlinear optical response and dipolar properties Julie Le Bescont, Chloé Breton-Patient 03/01/23 Journal of Molecular Liquids
How to Use Nested Probes Coupling to Increase the Local NMR/MRI Resolution and Sensitivity for Specific Experiments Mihaela Lupu, Joel Mispelter 02/01/23 Electronics (Switzerland)
Optimization of G-Quadruplex Ligands through a SAR Study Combining Parallel Synthesis and Screening of Cationic Bis(acylhydrazones) Oksana Reznichenko, Denis Leclercq, Jaime Franco Pinto, Liliane Mouawad, Anton Granzhan 01/18/23 Chemistry - A European Journal
Guidelines for G-quadruplexes: I. In vitro characterization Yu Luo, Anton Granzhan, Daniela Verga 01/01/23 Biochimie
G-quadruplex ligands as potent regulators of lysosomes Luo Yu 01/01/23 Autophagy
Novel Synthesis of IMC-48 and Affinity Evaluation with Different i-Motif DNA Sequences Joseph Boissieras, Anton Granzhan 01/01/23 Molecules
Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application Guillaume Bernadat 12/01/22 Nature Communications
Type I arginine methyltransferases are intervention points to unveil the oncogenic Epstein-Barr virus to the immune system Rahima Chennoufi, Patricia Duchambon, Marie Paule Teulade-Fichou 11/11/22 Nucleic Acids Research
Phen-DC<inf>3</inf> Induces Refolding of Human Telomeric DNA into a Chair-Type Antiparallel G-Quadruplex through Ligand Intercalation Marie Paule Teulade-Fichou 10/04/22 Angewandte Chemie - International Edition
Iso-FRET: an isothermal competition assay to analyze quadruplex formation in vitro Yu Luo, Daniela Verga 09/09/22 Nucleic Acids Research
Cytidine deaminase deficiency in tumor cells is associated with sensitivity to a naphthol derivative and a decrease in oncometabolite levels Céline Corcelle, Claire Beauvineau, Florence Mahuteau-Betzer 08/01/22 Cellular and Molecular Life Sciences
Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces Claire Beauvineau, Marie Paule Teulade-Fichou 08/01/22 Antimicrobial Agents and Chemotherapy
Traditional Systemic Treatment Options in Advanced Low-Grade Serous Ovarian Cancer after Successful Cytoreduction: A Systematic Review and Meta-Analysis Pascal Rigolet 08/01/22 Cancers
The Newly Sequenced Genome of Pisum sativum Is Replete with Potential G-Quadruplex-Forming Sequences—Implications for Evolution and Biological Regulation Yu Luo 08/01/22 International Journal of Molecular Sciences
Tyro3 Targeting as a Radiosensitizing Strategy in Bladder Cancer through Cell Cycle Dysregulation Linda Silina, Fatlinda Maksut, Pierre Verrelle, Frédérique Mégnin-Chanet 08/01/22 International Journal of Molecular Sciences
Increased PDT Efficacy When Associated with Nitroglycerin: A Study on Retinoblastoma Xenografted on Mice Mihaela Lupu, Florent Poyer, Philippe Maillard, Joel Mispelter 08/01/22 Pharmaceuticals
Effect of peripherical groups on the two-photon brightness of (E)-3-benzyl-6-bromo-2-styryl-3H-imidazo[4,5-b]pyridine derivatives Sandrine Piguel 07/15/22 Journal of Molecular Liquids
Photoactivatable V-Shaped Bifunctional Quinone Methide Precursors as a New Class of Selective G-quadruplex Alkylating Agents Sophie Bombard, Daniela Verga 06/21/22 Chemistry - A European Journal

Number of publications of the laboratory by scientific field (2016-2021)

Every paper can be classified in one or more scientific fields. The figure below shows the lab's number of publications in each scientific field, according to the ASJC classification (Elsevier)